The free fatty acid formed with digestion are absorbed mainly in the upper small intestine involving bile acids.
Trypsin formed from testosterone enanthate injection trypsinogen under the action of enterokinase in the small intestine and the like endopeptidase cleaves mainly linkages between peptides involving lysine and arginine.
According to recent clinical research, trypsin inhibits the mechanism of negative feedback the secretion of the pancreas.
it is believed that the analgesic effect of pancreatin described in some studies related to this.
Alpha-amylase as endoamilaza cleaves polysaccharides containing glucose.
Dimethicone, which is part of Pankreoflat, eliminates the increased accumulation of gas in the intestine.
Dimethicone – a chemically inert substance. Its mechanism of action is based on changing the surface tension of gas bubbles in the intestine. Gas bubbles are bursting and the gas in them is released and then absorbed or naturally derived.
Pancreatin and dimethicone are not absorbed from the gastrointestinal tract.
Indications for use
Impaired function of the pancreas (insufficiency exocrine function), for example, chronic inflammatory diseases of the pancreas (pancreatitis) or absence of gastric juice (ahiliya stomach).
Indigestion in the case of liver and biliary tract.
Indigestion after surgery on the stomach and small intestine, especially if these diseases are associated with increased gas formation and accumulation of gas in the intestines (flatulence).
: Hypersensitivity testosterone enanthate injection to pancreatin or other components of the drug, children under 12 years.
With careful preparation should be administered in the early stages of acute pancreatitis and exacerbation of chronic pancreatitis, and galactose intolerance, lactase deficiency or malabsorption of glucose-galactose.
Pregnancy and lactation
There are no data on the toxic effects on reproduction and fetal development.
However, since the study Caution should be exercised when administering the drug in pregnant and lactating women.
Dosing and Administration
The drug is taken by mouth without chewing, drinking plenty of fluids, during or after a meal.
Adults -. 1-2 tablets with each meal
for children under the age of 12 years, dose regimen selected individually by the attending physician.
Duration of the course treatment is determined by the doctor.
Side effects: For the skin: Possible allergic reactions in case of intolerance to any of the drug component. From the digestive system: Abdominal pain, discomfort in the stomach, constipation, diarrhea, nausea, vomiting, hyperuricosuria, increased levels of uric acid in blood plasma .
There is no information about possible symptoms of pancreatin / dimethicone overdose. With long-term use of the drug in high doses may develop hyperuricosuria, increased levels of uric acid in blood plasma.
The interaction with other drugs
simultaneous use of antacid preparations containing aluminum hydroxide and / or magnesium carbonate, may reduce the effectiveness of dimethicone.
There were no clinically significant cases pancreatin interaction with other drugs.
Testosterone enanthate injection contains active enzymes that release them when in the oral cavity can result in mucosal ulceration. The drug should be swallowed whole without chewing, with enough fluid.