One of the most important functions of the potassium ions is to keep the membrane potential of testosterone enanthate half life neurons and muscle cells, and the excitable myocardial tissue structures. The imbalance between the intracellular and extracellular potassium leads to a decrease in contractility of the heart, arrhythmias, tachycardia and the increase of digitalis toxicity.
Magnesium is an essential cofactor in more than 300 enzymatic reactions including energy metabolism and the synthesis of proteins and nucleic acids. In addition, magnesium plays a role in the heart: contraction and tension reducing heart rate, leading to a decrease in myocardial oxygen demand. Reduced contractility of smooth muscle cells leads to vasodilatation of the arterioles, including the coronary vessels and to increased coronary blood flow. Magnesium has antiischemic effect on myocardial tissue. The combination of potassium and magnesium ions in a single formulation is based on the fact that potassium deficiency in the body is often accompanied by magnesium deficiency and requires simultaneous correction levels of both ions, etc., while simultaneously correcting the levels of these electrolytes observed an additive effect ( low levels of potassium and / or magnesium has proaritmogenvym effect), in addition, potassium and magnesium reduce the toxicity of cardiac glycosides, without affecting the positive inotropic action of the latter.
Chronic heart disease (heart failure, a condition after myocardial infarction); heart rhythm disorders, primarily ventricular fibrillation (as an additional means);cardiac glycosides (as an adjunct) therapy.
Hypersensitivity to the drug, acute and chronic renal failure; Addison’s disease; atrioventricular block II, III degree; cardiogenic shock (blood pressure <90 mm Hg); hyperkalemia; gipermagniemiya.
Precautions: testosterone enanthate half life atrioventricular block of I degree.
Pregnancy and lactation
Data on the harmful effects of the drug during pregnancy and lactation are not available.
DOSAGE AND ADMINISTRATION
In a slow drip infusion containing 1-2 Pananginum ampoule.
For preparation of a solution for intravenous administration 1-2 contents of ampoules were dissolved in 50-100 ml of 5% glucose solution.
If necessary, the administration may be repeated after 4 -6 hours.
Perhaps Pananginum use in combination therapy.
With rapid intravenous possible development of hyperkalemia / gipermagniemii symptoms.
If overdose is possible: hyperkalemia, gipermagniemiya.
Treatment: removal of the drug, symptomatic therapy (intravenous infusion of 100 mg / min, calcium chloride), if necessary – dialysis.
INTERACTION WITH OTHER DRUGS
In the appointment testosterone enanthate half life together with potassium-sparing diuretics or angiotensin converting enzyme (ACE) inhibitors may develop hyperkalemia.
With the rapid introduction may develop skin redness.
It should be particularly careful in the case of diseases accompanied by hyperkalemia, it is recommended to monitor blood levels of ions.