testosterone cypionate vs enanthate

Testosterone cypionate vs enanthateis a combination of amoxicillin – semisynthetic penicillin with a broad spectrum of antibacterial activity and clavulanic acid – an irreversible inhibitor of beta-lactamases (II, III, IV, V type, activity against type I). Clavulanic acid forms a stable complex with said inactivated enzymes amoxicillin and protects against loss of antibacterial activity caused by production of b – lactamase as a major co-agents and pathogens and opportunistic microorganisms. This combination provides a high bactericidal activity.

Has a broad spectrum of antibacterial action. It is active against both sensitive strains to amoxicillin and against strains producing p-lactamase:

Gram-positive aerobes: Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus viridans, Streptococcus bovis, Staphylococcus aureus (methicillin-apart resistant strains), Staphylococcus epidermidis (methicillin-apart resistant strains), Listeria spp, Enteroccocus spp..

Gram-negative aerobes: Bordetella pertussis, Brucella spp, Campylobacter jejuni, Escherichia coli, Gardnerella vaginalis, Haemophilus influenzae, Haemophilus ducreyi, Klebsiella spp, Moraxella catarrhalis, Neisseria gonorrhoeae, Neisseria meningitidis, Pasteurella multocida, Proteus spp, Salmonella spp, Shigella…. spp., Vibrio cholerae, Yersenia enterocolitica .

Anaerobes: Peptococcus spp, Peptostreptococcus spp, of Clostridium spp, of Bacteroides spp, of Actinomyces israelii…..

Pharmacokinetics:
Basic pharmacokinetic parameters of amoxicillin and clavulanic acid are similar. Both testosterone cypionate vs enanthate components are well absorbed after oral administration, food intake does not affect the extent of absorption. Peak plasma concentration is reached after about 1 hour after ingestion.

Both components are characterized by good volume distribution in body fluids and tissues (lungs, middle ear, pleural and peritoneal fluid, uterus, ovaries, etc.). Amoxicillin also penetrates into the synovial fluid, liver, prostate, tonsils, muscle tissue, the gall bladder, the secret of the paranasal sinuses, saliva and bronchial secretions.

Amoxicillin and Clavulanic acid does not penetrate the blood-brain barrier with non-inflamed meninges. Amoxicillin and clavulanic acid penetrate the placental barrier and in trace concentrations excreted in breast milk.

Amoxicillin and Clavulanic acid is characterized by low plasma protein binding. Amoxicillin partially metabolized Clavulanic acid is exposed, apparently, metabolic rate.

Amoxicillin appears kidneys virtually unchanged by tubular secretion and glomerular filtration. Clavulanic acid is obtained by glomerular filtration and partly in the form of metabolites. Small quantities can be derived through the intestines and lungs. The half-life of amoxicillin and clavulanic acid is 1 – 1.5 hours. In patients with severe renal failure increases half-life to 7.5 hours to 4.5 amoxicillin and clavulanic acid for hours.

Both components are removed by hemodialysis and small amounts – peritoneal dialysis.

Indications
Infectious-inflammatory diseases caused by susceptible to the combination of amoxicillin / clavulanic acid strains:
Infections of the upper respiratory tract and upper respiratory tract (acute and chronic sinusitis, acute and chronic otitis, tonsillitis, pharyngitis).
Infections of the lower respiratory tract (acute and chronic bronchitis and pneumonia, pleural empyema).
urinary tract infection (including cystitis, urethritis, pyelonephritis).
Infections in gynecology (including salpingitis, oophoritis, endometritis, septic abortion).
Infections of bones and joints (including chronic osteomyelitis).
infections of the skin and soft tissues (including cellulitis, wound infection).
biliary tract infections (cholecystitis, cholangitis).
Diseases, sexually transmitted infections (gonorrhea, chancroid).
Odontogenic infections.

Contraindications:
Hypersensitivity to testosterone cypionate vs enanthate┬áthe drug, cephalosporins, and others. Beta-lactam antibiotics, infectious mononucleosis (including when a morbilliform rash), children up to 12 years (for a given dosage form). Precautions – Pregnancy, lactation, severe liver failure, gastrointestinal disease (including a history of colitis associated with the use of penicillins), chronic renal failure.

Pregnancy and lactation
During pregnancy can be used when the benefits of its use is much higher than the risk always exists when using any medication during pregnancy. If necessary, use suspend breastfeeding during lactation.

Dosing and Administration
The tablets should be taken orally with meals, not liquid, squeezed small amounts of water. Adults and children over 12 years (with a body weight over 40 kg), the usual dose in the case of mild and moderate course of infection is one tablet of 250 mg / 125 mg 3 times a day. In severe infections appoint 1 tablet 500/125 mg 3 times a day. The maximum daily dose of clavulanic acid (in potassium salt form) is for adults – 600 mg and 10 mg / kg body weight for children.

The maximum daily dose of amoxicillin is 6 g for adults and 45 mg / kg body weight for children. The course of treatment is 5-14 days.

The duration of treatment is determined by the attending physician. Treatment should not be extended beyond 14 days without re-medical examination. Odontogenic infection Dosage: 1 tablet 500 mg / 125 mg every 12 hours for 5 days. Dosage moderate renal impairment (creatinine clearance of 10-30 ml / min) is 1 tablet 500 mg / 125 mg every 12 hours or 1 tablet 250 mg / 125 mg (and with gentle to moderate), 2 times a day, with severe renal failure (creatinine clearance less than 10 mL / min) – 1 500/125 mg tablet once every 24 hours, or 1 tablet 250 mg / 125 mg (and with gentle to moderate), 1 time per day. When anuria dosing interval should be increased to 48 hours or more.

 

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